Liu, Xiaohua; Zhang, Yu; Huang, Wenjing; Tan, Wenfu; Zhang, Ao published an article on January 15 ,2018. The article was titled 《Design, synthesis and pharmacological evaluation of new acyl sulfonamides as potent and selective Bcl-2 inhibitors》, and you may find the article in Bioorganic & Medicinal Chemistry.HPLC of Formula: 1688-95-5 The information in the text is summarized as follows:
The antiapoptotic protein Bcl-2, overexpressed in many tumor cells, is an attractive target for potential small mol. anticancer drug discovery. Herein, we report a different structural modification approach on ABT-263 by merging the piperazinyl-Ph fragment into a bicyclic framework leading to a series of novel analogs, among which tetrahydroisoquinoline 13 was nearly equally potent against Bcl-2 as ABT-263. Further SAR in the P4-interaction pocket afforded the difluoroazetidine substituted analog 55, which retained good Bcl-2 activity with improved Bcl-2/Bcl-xL selectivity. In the experiment, the researchers used many compounds, for example, 4-Methyl-1-piperazinesulfonyl Chloride(cas: 1688-95-5HPLC of Formula: 1688-95-5)
4-Methyl-1-piperazinesulfonyl Chloride(cas: 1688-95-5) is a member of sulfamide. Sulfamide was used in the synthesis of: Schiff bases of the type ArCH=NSO2NH2; 1H,3H-2,1,3-benzothiadiazin-4-one-2,2-dioxide (BTDD); sulfamide analogs of oleoylethanolamide analogs in a study of PPARα activation.HPLC of Formula: 1688-95-5
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics