Synthetic Route of C5H11ClN2O2SOn March 11, 2013, Moukha-chafiq, Omar; Reynolds, Robert C. published an article in ACS Combinatorial Science. The article was 《Parallel Solution-Phase Synthesis of an Adenosine Antibiotic Analog Library》. The article mentions the following:
A library of eighty one adenosine antibiotic analogs was prepared under the Pilot Scale Library Program of the NIH Roadmap initiative from 5′-amino-5′-deoxy-2′,3′-O-isopropylidene-adenosine (I). Diverse aldehyde, sulfonyl chloride and carboxylic acid reactant sets were condensed to I, in solution-phase fashion, leading after acid-mediated hydrolysis to the targeted compounds in good yields and high purity. No marked antituberculosis or anticancer activity was noted on preliminary cellular testing, but these nucleoside analogs should be useful candidates for other types of biol. activity.4-Methyl-1-piperazinesulfonyl Chloride(cas: 1688-95-5Synthetic Route of C5H11ClN2O2S) was used in this study.
4-Methyl-1-piperazinesulfonyl Chloride(cas: 1688-95-5) is a member of sulfamide. Sulfamide was used in the synthesis of: Schiff bases of the type ArCH=NSO2NH2; 1H,3H-2,1,3-benzothiadiazin-4-one-2,2-dioxide (BTDD); sulfamide analogs of oleoylethanolamide analogs in a study of PPARα activation.Synthetic Route of C5H11ClN2O2S
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics