Obniska, Jolanta; Kulig, Katarzyna; Zejc, Alfred published an article in Acta Poloniae Pharmaceutica. The title of the article was 《Synthesis and anticonvulsant properties of new N-piperazinylalkyl imides of succinic acid》.Name: 1-Methylpiperazine dihydrochloride The author mentioned the following in the article:
A number of N-[((4-aryl)- or (4-methyl)-1-piperazinyl)alkyl]imides of 3-aryl- or 3,3-pentamethylenesuccinic acid, I [R1 = 3-ClC6H4, 4-ClC6H4, R2 = H, R1R2 = (CH2)5, R3 = Ph, CH2Ph, Me.2HCl, 2-MeOC6H4, 3-ClC6H4, n = 1; R1 = Ph, R2 = Ph, Me, R1R2 = (CH2)5, R3 = H.2HCl, Me.2HBr, Me.2HCl, n = 2, 3; R1 = Ph, R2 = Me, R3 = Ph, n = 3], were synthesized and tested for anticonvulsant activity in the maximum electroshock seizure (MES) and pentylenetetrazole seizure threshold (scMet) tests. Structures of the novel compounds were confirmed by elemental and spectral analyses. In addition to this study using 1-Methylpiperazine dihydrochloride, there are many other studies that have used 1-Methylpiperazine dihydrochloride(cas: 34352-59-5Name: 1-Methylpiperazine dihydrochloride) was used in this study.
1-Methylpiperazine dihydrochloride(cas: 34352-59-5) is used in the preparation of 2-(4-Methyl-1-piperazinylmethyl)acrylophenone(MPMAP), 1-methylpiperazine-1,4-diium tetrachloridozincate hemihydrate, 2-(4-Methyl-1-piperazinylmethyl)acrylophenone(MPMAP), an antimicrotubular drug..Name: 1-Methylpiperazine dihydrochloride
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics