Sut, A. Mrs.; Podesta, M. Mrs.; Lattes, M. A. published the artcile< N-Monoalkylation of some 2-oxo- and 2,5-dioxopiperazines>, Reference of 22476-74-0, the main research area is analgesics oxopiperazines; anesthetics oxopiperazines; piperazines oxo.
3,3-Diphenyl-2-oxopiperazine was heated with ethylene oxide and water at 120° 16 hrs. to give 3,3-diphenyl-4-(2-hydroxyethyl)-2-oxopiperazine, m. 172°. 3-Phenyl-4-(2-hydroxyethyl)-2-oxopiperazine, m. 99°, was similarly prepared Treatment of 3,3-dimethyl-2-oxopiperazine with ClCO2Et gave 3,3-dimethyl-4-ethoxycarbonyl-2-oxopiperazine, m. 150°, which on refluxing with Na and treatment with Ph-CH2Cl gave I (R = PhCH2), b3 180°, I [R = (CH2)2OAc], b3 150°, and I (R = Et), b3 120° were similarly prepared Acid hydrolysis of I gave HO2CCMe2NH(CH2)2NHR.2HCl (R and m.p. given): PhCH2, 230°; Et, 226°; HO(CH2)2, 190°. I (R = PhCH2) also gave 3,3-dimethyl-1-benzyl-2-oxopiperazine hydrochloride, m. 220°. Introduction of the hydroxyethyl group at the 4-position attenuated the anesthetic properties of 3,3-dimethyl-2-oxopiperazine, 3-phenyl-2-oxopiperazine, and 3,3-diphenyl-2-oxopiperazine while their analgesic properties were retained.
Chimica Therapeutica published new progress about Alkylation. 22476-74-0 belongs to class piperazines, and the molecular formula is C6H12N2O, Reference of 22476-74-0.
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics