The author of 《A novel water-soluble perylenetetracarboxylic diimide as a fluorescent pH probe: Chemosensing, biocompatibility and cell imaging》 were Georgiev, Nikolai I.; Said, Awad I.; Toshkova, Reneta A.; Tzoneva, Rumiana D.; Bojinov, Vladimir B.. And the article was published in Dyes and Pigments in 2019. Quality Control of 1-Methylpiperazine The author mentioned the following in the article:
Herein the authors pay attention to the design, synthesis and sensor activity of a novel biocompatible perylene-3,4,9,10-tetracarboxylic diimide (PDI) pH-probe in water. The synthesized compound shows selective fluorescence signaling properties as a function of pH (pKa value of 6.35±0.02) which makes the probe suitable for pH determination in the physiol. range. Thus prepared water soluble fluorescent system demonstrate low cytotoxicity to L929 cell lines from 330 μM to 1.3 μM and cell permeability in the lower concentration range. That findings show the high potential of the newly prepared PDI probe for monitoring of pH variations in bio-samples. The experimental process involved the reaction of 1-Methylpiperazine(cas: 109-01-3Quality Control of 1-Methylpiperazine)
1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Quality Control of 1-Methylpiperazine
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics