The author of 《New phenolic Mannich bases with piperazines and their bioactivities》 were Gul, Halise Inci; Tugrak, Mehtap; Gul, Mustafa; Mazlumoglu, Sertac; Sakagami, Hiroshi; Gulcin, Ilhami; Supuran, Claudiu T.. And the article was published in Bioorganic Chemistry in 2019. Safety of 1-Methylpiperazine The author mentioned the following in the article:
New Mannich bases, 2-(4-hydroxy-3-methoxy-5-((substituted piperazin-1-yl)methyl)benzylidene)-2,3-dihydro-1H-inden-1-ones I [R = Me, Ph, benzyl, etc.] were synthesized with the reaction of vanillin derived chalcone compound (2-(4-hydroxy-3-methoxybenzylidene)indan-1-one), paraformaldehyde and suitable amine in 1:1.2:1 mol ratios. Compounds I were evaluated in terms of cytotoxic/anticancer and CA inhibitory effects. According to the results obtained, the compounds I [R = Ph, 3-trifluoromethylphenyl] had the highest potency selectivity expression (PSE) values (60.6 and 19.2, resp.). On the other hand, the compounds I [R = benzyl] (Ki = 209.6 ± 70.2 pM) and [R = 3-methoxyphenyl] (Ki = 342.66 ± 63.72 pM) had the lowest Ki values in CA inhibition experiments towards hCA I and hCA II, resp. In conclusion, the compounds I [R = phenyl] (with cytotoxic/anticancer activity), I [R = benzyl] (with hCA I inhibiting activity) and I [R = 3-methoxyphenyl] (with hCA II inhibiting activity) can be leading compounds of the study for further designs and evaluations. In the experiment, the researchers used many compounds, for example, 1-Methylpiperazine(cas: 109-01-3Safety of 1-Methylpiperazine)
1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Safety of 1-Methylpiperazine
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics