《The presence of a cationic center is not alone decisive for the cytotoxicity of triterpene carboxylic acid amides》 was written by Brandes, Benjamin; Koch, Lukas; Hoenke, Sophie; Deigner, Hans-Peter; Csuk, Rene. Quality Control of 1-MethylpiperazineThis research focused onursolic acid piperazinylamide preparation antitumor structure activity; oleanolic acid piperazinylamide preparation antitumor structure activity; Amides; Cytotoxicity; N-oxide; Oleanolic acid; Ursolic acid. The article conveys some information:
3-O-Acetyl-ursolic acid and 3-O-acetyl-oleanolic acid were converted into piperazinylamides holding a distal NH, NMe or a NMe2 group. These compounds as well as the corresponding N-methyl-N-oxides were accessed. Their cytotoxicity was assessed in SRB assays employing a panel of human tumor cell lines and non-malignant fibroblasts (NIH 3T3). As a result, compounds holding a quaternary distal N-substituent were less cytotoxic that those holding a NH-moiety. Hence, the presence of a distal cationic center seems not to be a sufficient criterion for obtaining triterpenoids of high cytotoxicity and selectivity. In the experiment, the researchers used 1-Methylpiperazine(cas: 109-01-3Quality Control of 1-Methylpiperazine)
1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Quality Control of 1-Methylpiperazine
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics