Dubey, M.; Verma, V. K.; Shanker, K.; Sinha, J. N.; Bhargava, K. P.; Kishor, K. published an article on January 31 ,1979. The article was titled 《Synthesis of some newer piperazinoquinazolones as cardiovascular agents》, and you may find the article in Pharmazie.HPLC of Formula: 34352-59-5 The information in the text is summarized as follows:
Twenty-nine piperazinoquinazolones I (R1 = H, Cl, Br, I; R2 = H, Cl, Br; R3 = Me, Ph, 2- and 4-MeOC6H4, 3- and 4-ClC6H4) were prepared by Mannich reaction of II with HCHO and the appropriate piperazines. II were prepared in 40-60% yield by heating equimolar proportions of the appropriate acetanthranils with p-H2NC6H4COMe. Several I, e.g., I (R1 = R2 = H, R3 = Me, Ph, 2-MeOC6H4) elicited hypotensive activity. Several I elicited bradycardia and others produced tachycardia. Some others blocked the carotid occlusion response. In the experimental materials used by the author, we found 1-Methylpiperazine dihydrochloride(cas: 34352-59-5HPLC of Formula: 34352-59-5)
1-Methylpiperazine dihydrochloride(cas: 34352-59-5) is used in the preparation of 2-(4-Methyl-1-piperazinylmethyl)acrylophenone(MPMAP), 1-methylpiperazine-1,4-diium tetrachloridozincate hemihydrate, 2-(4-Methyl-1-piperazinylmethyl)acrylophenone(MPMAP), an antimicrotubular drug..HPLC of Formula: 34352-59-5
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics