Recommanded Product: 109-01-3In 2020 ,《One-pot multicomponent synthesis and bioevaluation of tetrahydroquinoline derivatives as potential antioxidants, a-amylase enzyme inhibitors, anti-cancerous and anti-inflammatory agents》 was published in Molecules. The article was written by Farooq, Samra; Mazhar, Aqsa; Ghouri, Areej; Ihsan-Ul-Haq; Ullah, Naseem. The article contains the following contents:
Mankind has always suffered from multiple diseases. Therefore, there has been a rigorous need in the field of medicinal chem. for the design and discovery of new and potent mol. entities. In this work, thirteen tetrahydroquinoline derivatives were synthesized and evaluated biol. for their antioxidant, a-amylase enzyme inhibitory, anti-proliferative and anti-inflammatory activities. SF8 showed the lowest IC50 of 29.19 ± 0.25 microg/mL by scavenging DPPH free radicals. SF5 showed significant antioxidant activity in total antioxidant capacity (TAC) and total reducing power (TRP) assays. SF5 and SF9 showed the maximum inhibition of a-amylase enzyme i.e., 97.47% and 89.93%, resp., at 200 microg/mL concentration Five compounds were shortlisted to determine their anti-proliferative potential against Hep-2C cells. The study was conducted for 24, 48 and 72 h. SF8 showed significant results, having an IC50 value of 11.9 ± 1.04 microM at 72 h when compared with standard cisplatin (IC50 value of 14.6 ± 1.01 microM). An in vitro nitric oxide (NO) assay was performed to select compounds for in vivo anti-inflammatory activity evaluation. SF13 scavenged the NO level to a maximum of 85% at 50 microM concentration, followed by SF1 and SF2. Based on the NO scavenging assay results, in vivo anti-inflammatory studies were also performed and the results showed significant activity compared to the standard, acetylsalicylic acid (ASA). In addition to this study using 1-Methylpiperazine, there are many other studies that have used 1-Methylpiperazine(cas: 109-01-3Recommanded Product: 109-01-3) was used in this study.
1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Recommanded Product: 109-01-3
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics