Kumar, Ravi R.; Kumar, Vijay; Kaur, Dilpreet; Nandi, Nilay K.; Dwivedi, Ashish R.; Kumar, Vinod; Kumar, Bhupinder published an article in 2021. The article was titled 《Investigation of Indole-3-piperazinyl Derivatives as Potential Antidepressants: Design, Synthesis, In-Vitro, In-Vivo and In-Silico Analysis》, and you may find the article in ChemistrySelect.Application of 109-01-3 The information in the text is summarized as follows:
In the current study, authors have designed and synthesized various indole functionalized piperazinyl derivatives I (n = 1, 2 and 3; R = CH(C6H5)2, C6H5, CH3, CH2C6H5 and CH2CH3) and evaluated them for in vitro MAO-A inhibitory activity and in vivo antidepressant-like activity. Most of the compounds were found to possess potent MAO-A inhibitory activity with IC50 values in the sub-micromolar range along with significant selectivity over MAO-B. Compounds I (n = 1; R = CH(C6H5)2) and I (n = 3; R = C6H5) emerged as the most promising reversible MAO-A inhibitors with IC50 values of 0.11±0.03μM and 0.14±0.02μM and displayed selectivity of 193 folds and 178 folds over Monoamine oxidase-B (MAO-B), resp. In the series, I (n = 1; R = CH(C6H5)2) showed good intracellular ROS inhibitory activity along with neuroprotective properties. These compounds were found nontoxic against SH-SY5Y cells and explored antidepressant activities. In the in vivo Forced swimming test (FST) and Tail suspension test (TST) studies, I (n = 1; R = CH(C6H5)2) exhibited potential antidepressant-like behavior similar to standard drug fluoxetine while compound I (n = 3; R = C6H5) showed antidepressant-like activity only in the TST studies. The mol. docking and dynamics studies further supported the results obtained in the in vitro and in vivo studies. Thus, the indole functionalized piperazinyl derivatives were found to be promising ligands and can be developed as new antidepressant mols. In the experimental materials used by the author, we found 1-Methylpiperazine(cas: 109-01-3Application of 109-01-3)
1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Application of 109-01-3
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics