The author of 《Antimicrotubular activity of 2-(4-methyl-1-piperazinylmethyl)acrylophenone dihydrochloride》 were Lesieur, I.; Delacourte, A.; Cazin, M.. And the article was published in Acta Therapeutica in 1984. Application In Synthesis of 1-Methylpiperazine dihydrochloride The author mentioned the following in the article:
The antimicrotubular activity of 3-(4-methyl-1-piperazinyl)propiophenone (I) [60868-01-1] was due to contamination of the synthetic product with 2-(4-methyl-1-piperazinylmethyl)acrylophenone (II) [91401-12-6]. Synthesis of I-2HCl [5470-92-8] and II-2HCl [91401-13-7] is described. Whereas I was devoid of any antimicrotubular activity, II, although less potent than colchicine, showed antimicrotubular activity. In addition to this study using 1-Methylpiperazine dihydrochloride, there are many other studies that have used 1-Methylpiperazine dihydrochloride(cas: 34352-59-5Application In Synthesis of 1-Methylpiperazine dihydrochloride) was used in this study.
1-Methylpiperazine dihydrochloride(cas: 34352-59-5) is used in the preparation of 2-(4-Methyl-1-piperazinylmethyl)acrylophenone(MPMAP), 1-methylpiperazine-1,4-diium tetrachloridozincate hemihydrate, 2-(4-Methyl-1-piperazinylmethyl)acrylophenone(MPMAP), an antimicrotubular drug..Application In Synthesis of 1-Methylpiperazine dihydrochloride
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics