Mallevais, M. L.; Delacourte, A.; Lesieur, I.; Lesieur, D.; Cazin, M.; Brunet, C.; Luyckx, M. published an article in Biochimie. The title of the article was 《2-(4-Methyl-1-piperazinylmethyl)acrylophenone dihydrochloride: a new antimicrotubular drug》.Safety of 1-Methylpiperazine dihydrochloride The author mentioned the following in the article:
2-(4-Methyl-1-piperazinylmethyl)acrylophenone (MPMAP)(I) [91401-12-6] possesses antimicrotubular activities. This compound inhibits 50% of the microtubule polymerization at a 3.10-5 M concentration It does not prevent tubulin paracrystal formation induced by vinblastine, and binding experiments reveal that this compound is a weak inhibitor of colchicine binding. The structure of this compound is different from the other antimicrotubular agents and has the advantage of being far less complex, highly soluble, and easy to synthesize. Thus, this and related compounds should be a new tool for the study of antimicrotubular activities and tubulin assembly. In the experiment, the researchers used many compounds, for example, 1-Methylpiperazine dihydrochloride(cas: 34352-59-5Safety of 1-Methylpiperazine dihydrochloride)
1-Methylpiperazine dihydrochloride(cas: 34352-59-5) is used in the preparation of 2-(4-Methyl-1-piperazinylmethyl)acrylophenone(MPMAP), 1-methylpiperazine-1,4-diium tetrachloridozincate hemihydrate, 2-(4-Methyl-1-piperazinylmethyl)acrylophenone(MPMAP), an antimicrotubular drug..Safety of 1-Methylpiperazine dihydrochloride
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics