Nagata, Mao; Yokooji, Tomoharu; Nakai, Tomoe; Miura, Yumika; Tomita, Takashi; Taogoshi, Takanori; Sugimoto, Yumi; Matsuo, Hiroaki published their research in Scientific Reports on December 31 ,2019. The article was titled 《Blockade of multiple monoamines receptors reduce insulin secretion from pancreatic beta cells》.Related Products of 70006-24-5 The article contains the following contents:
Clin. use of olanzapine frequently causes severe hyperglycemia as an adverse effect. In this study, we elucidated mechanisms by which olanzapine reduced insulin secretion using the hamster pancreatic beta cell line HIT-T15. Reverse transcriptional-PCR anal. revealed expression of dopamine (D2, D3 and D4), serotonin (5-HT2A, 5-HT2B, 5-HT2C, and 5-HT6), and histamine (H1 and H2) receptors in HIT-T15 cells. Olanzapine decreased insulin secretion from HIT-T15 cells at clin. relevant concentrations (64-160 nM). A dopamine D2 agonist, D3 antagonist, and D4 antagonist suppressed insulin secretion, whereas a D2 antagonist and D3 agonist increased it. A serotonin 5-HT2B agonist slightly increased insulin secretion, while a 5-HT2C antagonist slightly decreased it. Our results suggest that dopamine (D2, D3 and D4), serotonin (5-HT2B and 5-HT2C), and histamine (H1 and H2) receptors, which are expressed on pancreatic beta cells, directly modulate insulin secretion from pancreatic beta -cells. Thus, olanzapine may induce hyperglycemia in clin. settings by suppressing insulin secretion from beta cells through inhibition of dopamine D3, serotonin 5-HT2B and 5-HT2C, and histamine H1 receptors. In addition to this study using Abt-724, there are many other studies that have used Abt-724(cas: 70006-24-5Related Products of 70006-24-5) was used in this study.
Abt-724(cas: 70006-24-5) belongs to piperazines. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Related Products of 70006-24-5
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics