Ozenil, Marius; Skos, Lukas; Roller, Alexander; Gajic, Natalie; Holzer, Wolfgang; Spreitzer, Helmut; Platzer-Ozenil, Sonja; Vraka, Chrysoula; Hacker, Marcus; Wadsak, Wolfgang; Pichler, Verena published an article in 2021. The article was titled 《Unexpected scaffold rearrangement product of pirenzepine found in commercial samples》, and you may find the article in Scientific Reports.Synthetic Route of C5H12N2 The information in the text is summarized as follows:
Pharmacovigilance aims at a better understanding of the mol. events triggered by medications to prevent adverse effects, which despite significant advances in our anal. repertoire plague the use of drugs until today. In this study, we find that clin. prescribed and com. available pirenzepine may not be the correct compound Pirenzepine can undergo an unexpected scaffold rearrangement from the pharmaceutical active ingredient (API) to a previously uncharacterized benzimidazole. The rearrangement occurs under highly acidic conditions, which were believed to favor the dihydrochloride formation of pirenzepine. The rearranged products of pirenzepine and the structurally related telenzepine have significantly decreased affinity for the muscarinic acetylcholine receptor, the pharmacol. target of these compounds Fortunately, in situ rearrangement after oral application is no safety issue, as we show that reaction kinetics in gastric acid prevent rearrangement. The research community should consider appropriate measures to perform reliable receiving inspections in the com. supply of well described and frequently used chems., in particular if experiments yield unexpected results. After reading the article, we found that the author used 1-Methylpiperazine(cas: 109-01-3Synthetic Route of C5H12N2)
1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Synthetic Route of C5H12N2
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics