In 2019,Bioorganic Chemistry included an article by Zhang, Xiaoyu; Song, Qing; Cao, Zhongcheng; Li, Yan; Tian, Chaoquan; Yang, Ziyi; Zhang, Heng; Deng, Yong. Recommanded Product: 109-01-3. The article was titled 《Design, synthesis and evaluation of chalcone Mannich base derivatives as multifunctional agents for the potential treatment of Alzheimer’s disease》. The information in the text is summarized as follows:
A series of chalcone Mannich base derivatives were designed, synthesized and evaluated as multifunctional agents for the treatment of Alzheimer’s disease based on the multi-target directed ligands design strategy. In vitro assays demonstrated that most of the derivatives exerted potent selective inhibitory potency on AChE with good multifunctional properties. Among them, representative compound 7c exhibited moderate inhibitory potency for EeAChE (IC50 = 0.44 μM) and MAO-B inhibition (IC50 = 1.21 μM), good inhibitory effect on self-induced Aβ1-42 aggregation (55.0%, at 25 μM), biometal chelating property, moderate antioxidant activity with a value 1.93-fold of Trolox. Moreover, both kinetic anal. of AChE inhibition and mol. modeling study revealed that 7c showed a mixed-type inhibition, binding simultaneously to CAS and PAS of AChE. In addition, 7c also displayed high BBB permeability. These properties indicated 7c may be a promising multifunctional agent for the treatment of AD. In the experimental materials used by the author, we found 1-Methylpiperazine(cas: 109-01-3Recommanded Product: 109-01-3)
1-Methylpiperazine(cas: 109-01-3) can be used as mimic template in the preparation of molecularly imprinted microspheres (MIMs). It was also used to prepare the difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative..Recommanded Product: 109-01-3
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics