On August 1, 2012, Li, Qingeng; Wang, Tao; Xia, Biao; Guo, Bin published a patent.Category: piperazines The title of the patent was Novel 7,10-O,O-dimethyldocetaxel derivative, its preparation process and application for treating cancers. And the patent contained the following:
The invention disclosed a kind of 7,10-O,O-dimethyldocetaxel derivatives and their salts, preparation method and medical application as antitumor agents. The claimed title compounds are shown in structure I (R = H, Me, Et, Pr, iso-Pr, Bu, iso-Bu, or CH2-Ph; HB = inorganic or organic acid from HCl, HBr, HNO3, acetic acid, lactic acid, or tartaric acid etc.). The claimed compounds are prepared with II via esterification etc. multiple steps (procedure given). The obtained compounds and pharmaceutically acceptable salts can be used for preparing water-soluble medicals for treating cancers such as breast cancer, lung cancer and ovarian cancer without side effect, high safety and controlled quality (no data provided). The experimental process involved the reaction of 4-Ethyl-piperazine-1-carbonyl chloride(cas: 53788-12-8).Category: piperazines
The Article related to dimethyldocetaxel derivative salt synthesis esterification antitumor agent, Terpenes and Terpenoids: Diterpenes (C20), Including Gibberellins, Retinoids, Quassinoids, and Tocopherols and other aspects.Category: piperazines
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics