On December 13, 2012, Aissaoui, Hamed; Boss, Christoph; Corminboeuf, Olivier; Heidmann, Bibia; Siegrist, Romain published a patent.Synthetic Route of 890092-19-0 The title of the patent was Piperazines as antimalarial agents. And the patent contained the following:
The invention relates to novel piperazine derivatives and their use as active ingredients in the preparation of pharmaceutical compositions The invention also concerns related aspects including pharmaceutical compositions containing one or more of those compounds and their use as medicaments for the treatment or prevention of protozoal infections, such as especially malaria. The experimental process involved the reaction of 4-(4-Acetylpiperazin-1-yl)benzaldehyde(cas: 890092-19-0).Synthetic Route of 890092-19-0
The Article related to piperazine compound preparation antimalarial, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Synthetic Route of 890092-19-0
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics