Dong, Ze-Xi; Shi, Zhi-Hao; Li, Nian-Guang; Zhang, Wei; Gu, Ting; Zhang, Peng-Xuan; Wu, Wen-Yu; Tang, Yu-Ping; Fang, Fang; Xue, Xin; Li, He-Min; Cheng, Hai-Bo; Yang, Jian-Ping; Duan, Jin-Ao published an article in 2016, the title of the article was Design, Synthesis, and Biological Evaluation of Scutellarein Derivatives Based on Scutellarin Metabolic Mechanism In Vivo.Synthetic Route of 53788-12-8 And the article contains the following content:
Three series of scutellarein derivatives have been designed and synthesized based on metabolic mechanism of scutellarin (1) in vivo. Their thrombin inhibition activities were tested through the analyzation of prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), and fibrinogen (FIB). The antioxidant activities of these target products were assessed by 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) assay and the ability to protect PC12 cells against H2O2-induced cytotoxicity, and their solubilities were evaluated by UV spectrophotometer. The results showed that the two iso-Pr groups substituted derivative (18c) demonstrated stronger anticoagulant activity, better water solubility, and good antioxidant activity compared with scutellarein (2), which warrants further development of 18c as a promising agent for ischemic cerebrovascular disease treatment. The experimental process involved the reaction of 4-Ethyl-piperazine-1-carbonyl chloride(cas: 53788-12-8).Synthetic Route of 53788-12-8
The Article related to scutellarein derivative neuroprotectant antioxidant, antioxidant, scutellarein, scutellarin, solubility, thrombin, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Synthetic Route of 53788-12-8
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics