Heeres, J.; Backx, L. J. J.; Van Cutsem, J. published an article in 1984, the title of the article was Antimycotic azoles. 7. Synthesis and antifungal properties of a series of novel triazol-3-ones.Computed Properties of 67914-60-7 And the article contains the following content:
The antifungal triazolone derivatives I [R = H, Me, Q (X = N, CH); R1 = H, alkyl; R2 = H, Me) were prepared by a multistep sequence from 1-(p-methoxyphenyl)piperazine or MeSO3Q via piperazines III (R3 = H, Bz) and cyclization of III [R3 = C(:NH)NH2] with R2C(:NH)NH2. In vitro and in vivo antifungal properties of I are reported. Compound I [R = Q (X = N), R1 = MeEtCH, R2 = H], which displays a pronounced oral activity against vaginal candidosis in rats and against microsporosis in guinea pigs, was selected for clin. evaluation. The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).Computed Properties of 67914-60-7
The Article related to triazolone phenylpiperazinophenyl preparation fungicide, fungicide phenylpiperazinophenyltriazolone, piperazinophenyltriazolone phenyl, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Computed Properties of 67914-60-7
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics