On April 1, 1989, Lopez Molina, Isidro; Palomo Coll, Alberto; Domingo Coto, Antonio published a patent.Safety of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate The title of the patent was Preparation of ciprofloxacin hydrochloride monohydrate from ciprofloxacin hydrates. And the patent contained the following:
The antibacterial title compound (I.HCl.H2O) is prepared by acidification of I.xH2O (x = 1-4) with an oxonium acid RR1O+H Cl- (R, R1 = aliphatic or aromatic alkyl, alkoxyalkyl; or RR1 may form heterocyclic ring) in the presence of ≥1 lower aliphatic alc. and an ether R2OR3 (R2, R3 = as given for R, R1). The acid is prepared, possibly in situ, from HCl and ROR1. Thus, a suspension of 2 g I.2.5H2O (preparation given) in 15 mL dioxane and 5 mL MeOH was bubbled with HCl at 15-20° until acidic, followed by stirring, cooling to 5°, filtration, washing with dioxane, and air drying at 60° to give I.HCl.H2O in 99% yield. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Safety of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate
The Article related to ciprofloxacin hydrochloride monohydrate, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Safety of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics