Yang, Jiqiu; Liu, Lilin; Wang, Xiaoyan; Lu, Jiaguo; Sun, Changsheng; Zhang, Huanxiang; Zhou, Youjun; Zhang, Zhong published an article in 1984, the title of the article was Synthesis of an antifungal drug ketoconazole.Formula: C12H16N2O2 And the article contains the following content:
The title compound [I, R = p-(4-acetylpiperazin-1-yl)phenyl] was prepared by condensation of I (R = MeSO2) with piperazine II which was prepared starting from piperazine. The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).Formula: C12H16N2O2
The Article related to ketoconazole, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Formula: C12H16N2O2
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics