On May 27, 2010, Aissaoui, Hamed; Boss, Christoph; Corminboeuf, Olivier; Frantz, Marie-Celine; Grisostomi, Corinna published a patent.HPLC of Formula: 890092-19-0 The title of the patent was Novel bis-amides as antimalarial agents and their preparation and use in the treatment of protozoal infections. And the patent contained the following:
The invention relates to bis-amide derivatives of formula I and their use as active ingredients in the preparation of pharmaceutical compositions The invention also concerns related aspects including pharmaceutical compositions containing one or more of those compounds and their use as medicaments for the treatment or prevention of protozoal infections, such as especially malaria. Compounds of formula I wherein R1 is (un)substituted aryl and (un)substituted heteroaryl; R2 is (un)substituted aryl and (un)substituted heteroaryl: R3 is (un)substituted aryl and (un)substituted heteroaryl; R4R5 together with the N they are attached form morpholinyl, 2,3-dihydroindolinyl, 1,3-dihydroisoindolinyl, etc.; when R4 is H and C1-4 alkyl, then R5 is 1-benzylpyrrolidin-3-yl and 1-azabicyclo[2.2.2]oct-3-yl; when R4 is C1-4 alkyl then R5 is hydroxyethyl, alkoxyethyl, aminoethyl, etc.; and salts thereof, are claimed. Example compound II was prepared by a general procedure (procedure given). All the invention compounds were evaluated for their antimalarial activity. From the assay, it was determined that compound II exhibited an IC value of 5 nM. The experimental process involved the reaction of 4-(4-Acetylpiperazin-1-yl)benzaldehyde(cas: 890092-19-0).HPLC of Formula: 890092-19-0
The Article related to bis amide preparation antimalarial treatment protozoal infection, Aliphatic Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.HPLC of Formula: 890092-19-0
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics