On April 22, 2021, Berlin, Michael; Dong, Hanqing; Sherman, Dan; Snyder, Lawrence; Wang, Jing; Zhang, Wei published a patent.COA of Formula: C15H29N3O2 The title of the patent was Bifunctional molecules containing an E3 ubiquitin ligase binding moiety linked to a BCL6 targeting moiety and their preparation. And the patent contained the following:
Bifunctional compounds of formula I, which find utility as modulators of B-cell lymphoma 6 protein (BCL6; target protein), are described herein. Bifunctional compounds of formula I wherein ULM is a small E3 ubiquitin ligase binding moiety that bonds Von Hippel-Lindau, cereblon; PTM is a small mol. comprising a B-cell lymphoma 6 protein targeting moiety; L is a bond and a chem. linker; pharmaceutically acceptable salts, enantiomers, stereoisomers, solvates, and polymorphs thereof, are claimed. The bifunctional compounds of the disclosure exhibit a broad range of pharmacol. activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the disclosure. Example compound II was prepared by a general procedure (procedure given). The invention compounds were evaluated for their BCL6 protein degradation activity (some data given). The experimental process involved the reaction of tert-Butyl 4-(piperidin-4-ylmethyl)piperazine-1-carboxylate(cas: 1211568-27-2).COA of Formula: C15H29N3O2
The Article related to bifunctional mol preparation bcl6 protein degrader, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.COA of Formula: C15H29N3O2
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics