On July 23, 1992, Boettcher, Matthias; Jaehrling, Renate; Walther, Klaus; Haber, Hanka; Rackwitz, Christina; Mohs, Barbara; Franke, Rainer; Kuehne, Ronald; Koch, Andreas published a patent.Application In Synthesis of 4-Ethyl-piperazine-1-carbonyl chloride The title of the patent was Preparation of penicillin amides as antibacterials. And the patent contained the following:
Title compounds [I; R1 = H, acyl; R2 = H, OH; R3 = H, alkyl; R4 = Yn(CONH)mZpX; m, n, p = 0, 1; Y, Z = alkyl; X = (substituted) aryl, heterocyclic; or R3R4N = (substituted) heterocycyl], were prepared Thus, piperacillin in CH2Cl2 containing Et3N at -10° was treated with ClCO2CHMe2 and then with PhCH2NH2 in CH2Cl2 to give 78% piperacillin benzylamide. I showed min. inhibitory concentrations of 4-8 mM/mL against Pseudomonas aeruginosa SG 137. The experimental process involved the reaction of 4-Ethyl-piperazine-1-carbonyl chloride(cas: 53788-12-8).Application In Synthesis of 4-Ethyl-piperazine-1-carbonyl chloride
The Article related to penicillin amide preparation antibacterial, Biomolecules and Their Synthetic Analogs: Beta-Lactam Fungal Metabolites and other aspects.Application In Synthesis of 4-Ethyl-piperazine-1-carbonyl chloride
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics