On November 20, 2019, Daneshyar, Anahita; Nematollahi, Davood; Varmaghani, Fahimeh; Goljani, Hamed; Alizadeh, Hojjat published an article.Reference of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone The title of the article was Electrochemical synthesis of a new phosphonium betaine. Kinetic evaluation and antibacterial susceptibility. And the article contained the following:
Cyclic voltammetry, controlled-potential coulometry, chronoamperometry, chronocoulometry and chronopotentiometry methods were used for the electrochem. study of 1-acetyl-4-(4-hydroxyphenyl)piperazine (APIP) in the presence of PPh3 (TPP) as a nucleophile. Electrochem. generated APIPox can serve as a Michael acceptor for nucleophilic attack by TPP to yield a new phosphonium betaine (APTP). The authors prepared a new product in good yield and purity by reaction of TPP with APIPox in an undivided cell equipped with C anode. Based on an EC mechanism, the observed homogeneous rate constant (kobs) of the Michael addition reaction of APIPox with TPP were estimated by comparing the exptl. cyclic voltammograms with the digital simulated results. Also, electrochem. oxidation of APIP was studied both exptl. and theor. to provide insight into the influence of natural charge and thermodn. stability parameters on the type of chem. reaction which follows APIPox. The synthesized compound was evaluated for in vitro antibacterial. The experimental process involved the reaction of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone(cas: 67914-60-7).Reference of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone
The Article related to electrochem synthesis phosphonium betaine kinetics antibacterial susceptibility, antibacterial agents, chronoamperometry, chronopotentiometry, coulometry, cyclic voltammetry, glassy carbon electrodes, ir spectra, lumo (molecular orbital), mass spectra, nmr (nuclear magnetic resonance), reaction mechanism and other aspects.Reference of 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics