On March 21, 1990, Kishimoto, Shoji; Fujita, Takeshi published a patent.Quality Control of 4-Ethyl-piperazine-1-carbonyl chloride The title of the patent was Preparation of O-acylfumagillol derivatives as angiogenesis inhibitors. And the patent contained the following:
The title compounds [I; R1 = CH:CMe2, (un)substituted CH2CHMe2; R2 = substituted alkanoyl, aroyl, (un)substituted heterocyclylcarbonyl, CONH2, alkyl, etc.] were prepared, e.g., by acylation of I (R2 = H). Thus, fumagillol was stirred 20 h with diglycolic anhydride in pyridine to give I (R1 = COCH2OCH2CO2H, R2 = CH:CMe2) which reduced bovine fibroblast growth factor-induced angiogenesis in cornea of 8 of 8 rats evaluated after 7 days. The experimental process involved the reaction of 4-Ethyl-piperazine-1-carbonyl chloride(cas: 53788-12-8).Quality Control of 4-Ethyl-piperazine-1-carbonyl chloride
The Article related to fumagillol substituted preparation angiogenesis inhibitor, Terpenes and Terpenoids: Sesquiterpenes (C15), Including Ionones and other aspects.Quality Control of 4-Ethyl-piperazine-1-carbonyl chloride
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics