On November 28, 1996, Ali, Yusuf; Jani, Rajni published a patent.Application In Synthesis of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate The title of the patent was Antibacterial ophthalmic compositions containing synergistic combination of ciprofloxacin and a polystyrene sulfonic acid polymer. And the patent contained the following:
Aqueous pharmaceutical compositions containing a synergistic combination of ciprofloxacin (I) and a polystyrene sulfonic acid polymer (PSSA) (Markush structure given) are described, wherein the compositions are clear solutions which are comfortable and have sustained-release action. An ophthalmic pharmaceutical solution contained I.HCl.H2O (equivalent to 0.3% as base) 0.35, mannitol 4.4, boric acid 0.3, NaOH and/or HCl 0.3%, 2% PSSA solution 50, and water q.s. 100 mL. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Application In Synthesis of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate
The Article related to antibacterial ophthalmic pharmaceutical synergism ciprofloxacin, polystyrene sulfonic acid polymer ophthalmic pharmaceutical, Pharmaceuticals: Formulation and Compounding and other aspects.Application In Synthesis of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics