Fan, Mengtian; Wu, Jinghong; Li, Xian; Jiang, Yingjiu; Wang, Xiaowen; Bie, Mengjun; Weng, Yaguang; Chen, Sicheng; Chen, Bin; An, Liqin; Zhang, Menghao; Huang, Gaigai; Zhu, Mengying; Shi, Qiong published an article in 2021, the title of the article was CX3CL1 promotes tumour cell by inducing tyrosine phosphorylation of cortactin in lung cancer.SDS of cas: 380843-75-4 And the article contains the following content:
It has been reported that chemokine CX3CL1 can regulate various tumors by binding to its unique receptor CX3CR1. However, the effect of CX3CL1-CX3CR1 on the lung adenocarcinoma and lung squamous cell carcinoma is still unclear. Here, we showed that CX3CL1 can further invasion and migration of lung adenocarcinoma A549 and lung squamous cell carcinoma H520. In addition, Western blot and immunofluorescence test indicated CX3CL1 up-regulated the phosphorylation level of cortactin, which is a marker of cell pseudopodium. Meanwhile, the phosphorylation levels of c-Src and c-Abl, which are closely related to the regulation of cortactin phosphorylation, are elevated. Nevertheless, the src/abl inhibitor bosutinib and mutations of cortactin phosphorylation site could inhibit the promotion effect of CX3CL1 on invasion and migration of A549 and H520. Moreover, these results of MTT, Hoechst staining and Western blot suggested that CX3CL1 had no effect on the proliferation and apoptosis of A549 and H520 in vitro. The effects of CX3CL1 were also verified by the s.c. tumor formation in nude mice, which showed that it could promote proliferation and invasion of A549 in vivo. In summary, our results indicated that CX3CL1 furthered invasion and migration in lung cancer cells partly via activating cortactin, and CX3CL1 may be a potential mol. in regulating the migration and invasion of lung cancer. The experimental process involved the reaction of 4-((2,4-Dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile(cas: 380843-75-4).SDS of cas: 380843-75-4
The Article related to lung cancer cx3cl1 tyrosine phosphorylation, cx3cl1, cancer, cortactin, invasion, lung, Mammalian Pathological Biochemistry: Oncology and other aspects.SDS of cas: 380843-75-4
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