Puga, Ana M.; Rey-Rico, Ana; Magarinos, Beatriz; Alvarez-Lorenzo, Carmen; Concheiro, Angel published an article in 2012, the title of the article was Hot melt poly-ε-caprolactone/poloxamine implantable matrices for sustained delivery of ciprofloxacin.Application of 86393-32-0 And the article contains the following content:
It has been suggested that prevention and treatment of osteomyelitis could be achieved through local drug delivery using implantable devices, which provide therapeutic levels at the infection site with min. side-effects. Phys. blends of polycaprolactone (PCL) and poloxamine (Tetronic) were prepared by applying a solvent-free hot melting approach to obtain cytocompatible implants with a tunable bioerosion rate, ciprofloxacin release profile and osteoconductive features. Differential scanning calorimetry and X-ray anal. indicate that the hydrophilic poloxamine varieties T908, T1107, and T1307 are miscible with PCL, while the hydrophobic block copolymer T1301 is immiscible. Incorporation of the block copolymer at weight ratios ranging from 25 to 75 weight% led to matrixes with viscoelastic parameters in the range of those of fresh cortical bone. Once immersed in buffer the matrixes underwent a similar weight loss in the first week to the content of poloxamine, followed by a slower erosion rate due to PCL. The initial rapid erosion and the increase in porosity partially explain the observed burst of ciprofloxacin release, which is more intense in the PCL:T1301 formulation due to drug/T1301 repulsion due to polarity. The matrixes sustained ciprofloxacin release for several months (<50% released after 3 mo) and showed in vitro efficacy against Staphylococcus aureus, eradicating the bacteria in less than 48 h. PCL:poloxamine was cytocompatible with osteoblasts and the matrixes prepared with low proportions of T908 were also compatible with mesenchymal stem cell differentiation to osteoblasts. The influence of the nature and proportion of temperature-responsive poloxamine on the performance of PCL implantable systems was determined The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Application of 86393-32-0
The Article related to polycaprolactone tetronic dissolution hot melting ciprofloxacin hydrochloride monohydrate antibacterial, osteogenic sarcoma osteogenesis, Pharmaceuticals: Formulation and Compounding and other aspects.Application of 86393-32-0
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