On May 11, 2006, Dillen, Kathleen; Vandervoort, Jo; Van den Mooter, Guy; Ludwig, Annick published an article.Electric Literature of 86393-32-0 The title of the article was Evaluation of ciprofloxacin-loaded Eudragit RS100 or RL100/PLGA nanoparticles. And the article contained the following:
The objective of present study was to prepare pos. charged ciprofloxacin-loaded nanoparticles providing a controlled release formulation. The particles were prepared by water-in-oil-in-water (w/o/w) emulsification and solvent evaporation, followed by high-pressure homogenization. Two non-biodegradable pos. charged polymers, Eudragit RS100 and RL100, and the biodegradable polymer poly(lactic-co-glycolic acid) or PLGA were used alone or in combination, with varying ratios. The formulations were evaluated in terms of particle size and zeta potential. Differential scanning calorimetry measurements were carried out on the nanoparticles and on the pure polymers Eudragit and PLGA. Drug loading and release properties of the nanoparticles were examined The antimicrobial activity against Pseudomonas aeruginosa and Staphylococcus aureus was determined During solvent evaporation, the size and zeta potential of the nanoparticles did not change significantly. The mean diameter was dependent on the presence of Eudragit and on the viscosity of the organic phase. The zeta potential of all Eudragit containing nanoparticles was pos. in ultrapure water (around +21/+25 mV). No burst effect but a prolonged drug release was observed from all formulations. The particles’ activity against P. aeruginosa and S. aureus was comparable with an equally concentrated ciprofloxacin solution The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Electric Literature of 86393-32-0
The Article related to ciprofloxacin eudragit polylactide polyglycolide nanoparticle, Pharmaceuticals: Formulation and Compounding and other aspects.Electric Literature of 86393-32-0
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