Han, Yue; Bai, Can; He, Xi-Meng; Ren, Qing-Ling published an article in , the title of the article was P2X7 receptor involved in antitumor activity of atractylenolide I in human cervical cancer cells.HPLC of Formula: 1428327-31-4 And the article contains the following content:
Atractylenolide I (Atr-I) was found to sensitize a variety of human cancer cells in previous studies. Purinergic P2X7R plays important role in different cancers. However, whether Atr-I could generate antitumor activity in human cervical cancer cells and P2X7R get involved in this effect remain unclear. In this study, Hela (HPV 18 +) and SiHa (HPV 16 +) cells were treated with different doses of Atr-I. The results indicated that agonist and antagonist of P2X7 receptors, BzATP and JNJ-47965567 (JNJ), could suppress the proliferation of Hela and SiHa cells. Atr-I demonstrated a considerable antitumor effect in both human cervical cancer cells in vitro. Atr-I combined with P2X7R agonist, BzATP, restored Atr-I-induced growth inhibition in Hela cells but not in SiHa cells. However, the combinatorial treatment of P2X7R antagonist JNJ and Atr-I has an additive effect on cell growth inhibition in SiHa cells rather than in Hela cells. It implied that P2X7R would get involved in the anti-human cervical cancer cells effect of Atr-I. The experimental process involved the reaction of N-((4-(4-Phenylpiperazin-1-yl)tetrahydro-2H-pyran-4-yl)methyl)-2-(phenylthio)nicotinamide(cas: 1428327-31-4).HPLC of Formula: 1428327-31-4
The Article related to atractylenolide anticancer agent p2x7 receptor cervical cancer, atractylenolide i, hela cells, human cervical cancer cells, p2x7rs, siha cells, Placeholder for records without volume info and other aspects.HPLC of Formula: 1428327-31-4
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics