On July 17, 2001, Lee, Fang-yu published a patent.Quality Control of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate The title of the patent was Oral antimicrobial formulations of ciprofloxacin. And the patent contained the following:
The invention provides 3 oral ciprofloxacin formulations, with the first formulation comprising 60-75% ciprofloxacin or its salt, 0.3-10% pregelatinized starch as binder, 5-30% lactose as diluent, 1-10% of sodium starch glycolate as disintegrant and 0.5-2% magnesium stearate as lubricant. The second formulation comprises 60-75% ciprofloxacin or its salt, 1-5% polyvinylpyrrolidone as binder, 5-30% lactose as diluent; 1-10% sodium starch glycolate as disintegrant, and 0.5-2% magnesium stearate as lubricant. The third formulation comprises 60-75% ciprofloxacin or salt, 1-8% poly(vinyl alc.) as binder, 5-30% lactose as diluent, 1-10% sodium starch glycolate as disintegrant, and 0.5-2% magnesium stearate as lubricant. The ciprofloxacin, the binder, the diluent, the disintegrant, and the lubricant are first mixed in a dry state to form a powder mixture, followed by mixing with a water-solvent solution to convert the dry powder mixture into a wet powder mixture before grinding and granulating the wet powder mixture into wet granules, which are further dried to form dry granules. The above 3 formulations do not contain cellulose. Thus, tablets contained ciprofloxacin 70, PVP-K30 2, sodium starch glycolate 5, lactose 21, and Mg stearate 2%. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Quality Control of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate
The Article related to antimicrobial ciprofloxacin oral, Pharmaceuticals: Formulation and Compounding and other aspects.Quality Control of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics