On March 20, 2005, Pshenichnikov, V. G.; Frolova, L. V.; Zaripova, Z. I.; Dmitrieva, I. M.; Besh, E. A.; Mokhnacheva, E. V.; Anishchenko, S. S.; Predeina, N. I. published a patent.Category: piperazines The title of the patent was Eye drops and method for obtaining them. And the patent contained the following:
The present innovation deals with medicinal preparations designed as solution and indicated for therapeutic needs. Eye drops contain ciprofloxacin hydrochloride monohydrate equivalent to 0.3% free base, a buffer system that keeps pH within 3.5-5.5 interval, as a conserving agent – benzalkonium chloride and as a stabilizer – the salt of disodium ethylenediamine tetraacetic acid; moreover, their range of osmolality values correspond to 150-450 mM/kg H2O. Eye drops should be obtained by preparing a buffer system in which mannitol should be dissolved followed by the salt of disodium ethylenediamine tetraacetic acid, benzalkonium chloride, and ciprofloxacin hydrochloride. Then one should perform the control for the quality of the obtained solution, which then is filtered by applying sterilizing elements and packed. This innovation provides treatment of eyes at certain desired osmolality. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Category: piperazines
The Article related to eye drop ciprofloxacin formulation, Pharmaceuticals: Formulation and Compounding and other aspects.Category: piperazines
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics