On January 3, 2008, Tornero Montano, Jose Ruben; Quintana Hau, Juan De Dios; Baiza Duran, Leopoldo Martin; Rodriguez Franco, Norma Patricia; Gonzalez, Jaime R.; Jimenez Bayardo, Arturo published a patent.Formula: C17H21ClFN3O4 The title of the patent was An ophthalmic formulation in suspension of loteprednol etabonate and ciprofloxacin hydrochloride. And the patent contained the following:
The invention concerns a topically applied ophthalmic formulation in suspension which contains loteprednol etabonate and ciprofloxacin hydrochloride. Moreover, said formulation contains a polymer as a thickening agent which is derived from the acrylic acid known generically as Carbopol, a nonionic surfactant, an ionic tonicity agent and a nonionic tonicity agent, which are physico-chem. compatible, stable and appropriately dissolved in the suspension. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Formula: C17H21ClFN3O4
The Article related to loteprednol etabonate ciprofloxacin ophthalmic formulation, Pharmaceuticals: Formulation and Compounding and other aspects.Formula: C17H21ClFN3O4
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics