On March 31, 2000, Tsvetkov, Plamen K.; Velikova, Evtimija I; Kafedzhiiski, Stefan K.; Stoyanov, Simeon I; Dimitrova, Silvija S.; Evstatieva, Anka V; Stoyanova, Evgenija K. published a patent.SDS of cas: 86393-32-0 The title of the patent was Composition and method for the preparation of a medicament dosage form. And the patent contained the following:
The invention relates to a composition and method for the preparation of a medicament form based on 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-1-(1-piperazinyl)-quinolin-3-carboxylic acid monohydrochloride, known as ciprofloxacin, which is applied as antibacterial medicine in the medical practice. The composition includes: ciprofloxacin hydrochloride monohydrate and lactose monohydrate in ratio 4.93:1, mannitol SD 200, microcrystalline cellulose, sodium starch glycolate, colloid silicon dioxide, talcum and magnesium stearate. The medicamentous form is produced when ciprofloxacin and lactose monohydrate are mixed in a mixer granulator and are homogenized at speeds: 98 r.p.m. for the small blade, and 1500 r.p.m. for the large blade. Sep., the dissolved sodium starch glycolate is added at continuous agitation to the homogenized mixture Granular mass is produced which is dried at 45-50°C to residual moisture of 3% and is calibrated. To the dry granular mass mannitol SD 200, microcrystalline cellulose, sodium starch glycolate, colloid silicon dioxide, talcum and magnesium stearate. The medicamentous form is produced when ciprofloxacin and lactose monohydrate are mixed in a mixer granulator and are homogenized at speeds: 98 r.p.m. for the small blade, and 1500 r.p.m. for the large blade. Sep., the dissolved sodium starch glycolate is added at continuous agitation to the homogenized mixture Granular mass is produced which is dried at 45-50°C to residual moisture of 3% and is calibrated. To the dry granular mass mannitol SD 200, microcrystalline cellulose, colloidal silicon dioxide, talcum and magnesium stearate are added. The mixture produced is homogenized. A water impermeable layer of a film with Opadry is applied. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).SDS of cas: 86393-32-0
The Article related to ciprofloxacin dosage film tablet, Pharmaceuticals: Formulation and Compounding and other aspects.SDS of cas: 86393-32-0
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics