On December 4, 2008, Souza, Fabio Eduardo Silva; Oudenes, Jan; Gorin, Boris Ivanovich published a patent.Formula: C17H21ClFN3O4 The title of the patent was Anhydrous ciprofloxacin hydrochloride. And the patent contained the following:
The present invention provides a new anhydrous crystalline form of ciprofloxacin-HCl that is substantially free from solvent mols., and processes of preparation thereof. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Formula: C17H21ClFN3O4
The Article related to ciprofloxacin hydrochloride anhydrous, Pharmaceuticals: Pharmaceutics and other aspects.Formula: C17H21ClFN3O4
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics