On September 30, 2004, Weyenberg, W.; Vermeire, A.; D’Haese, E.; Vanhaelewyn, G.; Kestelyn, P.; Callens, F.; Nelis, H. J.; Remon, J. P.; Ludwig, A. published an article.Formula: C17H21ClFN3O4 The title of the article was Effect of different sterilisation methods on the properties of bioadhesive powders and ocular minitablets, and clinical evaluation. And the article contained the following:
The purpose of this study was to evaluate the influence of gamma-irradiation and dry heat sterilization on the properties of a bioadhesive powder mixture containing ciprofloxacin and its corresponding ocular minitablets. The mol. weight characteristics of drum dried waxy maize starch (DDWM), employed as major component of the bioadhesive formulation, the decay kinetics of radicals, the rheol. properties of the bioadhesive polymers and the microbial activity of ciprofloxacin were studied. The influence of the different sterilization methods on the characteristics of the ocular minitablets was investigated by measuring the crushing strength, the friability, and the in vitro release of ciprofloxacin from the minitablets. Finally, the clin. value of the selected sterilized minitablets was evaluated in seven healthy volunteers. Both sterilization methods similarly affected the properties of the bioadhesive formulation by inducing stable radicals and decreasing the mol. weight of DDWM, although no changes in the microbiol. activity of ciprofloxacin were measured. An obvious influence of both sterilization methods was observed in the in vitro release study. The crushing strength and friability of the minitablets were not significantly influenced by gamma-irradiation Based on these data, gamma-irradiation was more adequate as sterilization method for the bioadhesive ocular minitablets than dry heat sterilization, because it affected the least the phys. properties of the minitablets. Therefore, the gamma-sterilized minitablets were selected for an in vivo evaluation in seven volunteers. The concentration of ciprofloxacin in the tear film remained above its MIC value for the most common ocular pathogens for at least 8 h. Consequently, the gamma-irradiated minitablets containing ciprofloxacin can be considered as a promising formulation to treat bacterial keratitis and conjunctivitis. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Formula: C17H21ClFN3O4
The Article related to bioadhesive powder ocular minitablet sterilization, Pharmaceuticals: Pharmaceutics and other aspects.Formula: C17H21ClFN3O4
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics