Widyastuti, Indah; Ainurofiq, Ahmad; Soewandhi, Sundani Nurono published an article in 2019, the title of the article was Effects of thermal energy, mechanical energy, and solvent on ciprofloxacin hydrochloride monohydrate physicochemical properties.SDS of cas: 86393-32-0 And the article contains the following content:
Ciprofloxacin HCl is available in the form of anhydrate and monohydrate. Water content can affect the hydrolysis, hygroscopicity, bond, and crystal properties of an active substance. This study was aimed to observe the physicochem. phenomena that occur in ciprofloxacin HCl monohydrate because of thermal energy, mech. energy, and solvent. Ciprofloxacin HCl monohydrate from two different producers were given treatments by thermal energy, mech. energy, and solvent. Afterward, the ingredients were characterized using XRD, DSC, and SEM. Other than that, crystal habit, modulus of elasticity, and dissolution were assessed. The results of characterization before and after treatment were compared to observe any changes. Ciprofloxacin HCl monohydrate from two different producers showed similarities in physicochem. properties. Manufacture treatment, which includes thermal energy, mech. energy, and solvent, affected the physicochem. characteristics of ciprofloxacin HCl monohydrate. The effect of thermal energy and solvent can change ciprofloxacin from hydrate to anhydrate, thus changed its dissolution level. Meanwhile, mech. effect by grinding and compression can decrease crystallinity and change the particle size of ciprofloxacin HCl monohydrate, thus change its dissolution level. The results of this study showed that the process of manufacturing can change the physicochem. characteristics of ciprofloxacin HCl monohydrate. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).SDS of cas: 86393-32-0
The Article related to ciprofloxacin hydrochloride monohydrate solvent thermal mech energy physicochem property, crystal structure, mechanical energy, particle size, physical and chemical properties, solvents and other aspects.SDS of cas: 86393-32-0
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics