Barry, Arthur L. published the artcileIn vitro activities of temafloxacin, tosufloxacin (A-61827) and five other fluoroquinolone agents, Application of Temafloxacin hydrochloride, the main research area is fluoroquinolone temafloxacin tosufloxacin bacteria inhibition; A61827 fluoroquinolone comparison bacteria inhibition.
Tosufloxacin (A-61827) is the tosylate salt of A-60969 (T-3262). Temafloxacin (A-62254) is the HCl salt of A-63004. Both compounds were tested against 945 aerobic bacterial isolates and their in vitro activities were compared to those of 5 other fluoroquinolones. Ciprofloxacin and tosufloxacin were similar in their activity against the Enterobacteriaceae and Pseudomonas species. Temafloxacin and ofloxacin were similar in their activity against the Gram-neg. bacilli. Strains that were susceptible to ciprofloxacin were also susceptible to ofloxacin, temafloxacin, and tosufloxacin. Against nalidixic acid-resistant enteric bacilli, the potency of all 7 fluoroquinolones was compromised. Enoxacin and fleroxacin were the least active drugs against Gram-pos. species. Tosufloxacin was particularly active against the gram-pos. species; ciprofloxacin, difloxacin, and temafloxacin were less active.
Journal of Antimicrobial Chemotherapy published new progress about fluoroquinolone temafloxacin tosufloxacin bacteria inhibition; A61827 fluoroquinolone comparison bacteria inhibition. 105784-61-0 belongs to class piperazines, name is Temafloxacin hydrochloride, and the molecular formula is C21H19ClF3N3O3, Application of Temafloxacin hydrochloride.
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics