Gu, Chong-Hui published the artcilePredicting effect of food on extent of drug absorption based on physicochemical properties, Formula: C21H19ClF3N3O3, the main research area is food drug interaction absorption surface area polarity solubility pharmacokinetics.
To develop a statistical model for predicting effect of food on the extent of absorption (area under the curve of time-plasma concentration profile, AUC) of drugs based on physicochem. properties. Logistic regression was applied to establish the relationship between the effect of food (pos., neg. or no effect) on AUC of 92 entries and physicochem. parameters, including clin. doses used in the food effect study, solubility (pH 7), dose number (dose/solubility at pH 7), calculated Log D (pH 7), polar surface area, total surface area, percent polar surface area, number of hydrogen bond donor, number of hydrogen bond acceptors, and maximum absorbable dose (MAD). For compounds with MAD ≥ clin. dose, the food effect can be predicted from the dose number category and Log D category, while for compounds with MAD < clin. dose, the food effect can be predicted from the dose number category alone. With cross validation, 74 out of 92 entries (80%) were predicted into the correct category. The correct predictions were 97%, 79%, and 68% for compounds with pos., neg. and no food effect, resp. A logistic regression model based on dose, solubility, and permeability of compounds is developed to predict the food effect on AUC. Statistically, solubilization effect of food primarily accounted for the pos. food effect on absorption while interference of food with absorption caused neg. effect on absorption of compounds that are highly hydrophilic and probably with narrow window of absorption. Pharmaceutical Research published new progress about Acidity. 105784-61-0 belongs to class piperazines, name is Temafloxacin hydrochloride, and the molecular formula is C21H19ClF3N3O3, Formula: C21H19ClF3N3O3.
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics