Hardy, Dwight J. published the artcileComparative antibacterial activities of temafloxacin hydrochloride (A-62254) and two reference fluoroquinolones, Synthetic Route of 105784-61-0, the main research area is temafloxacin antibacterial.
The in vitro and in vivo properties of a new 1-difluorophenyl-6-fluoroquinolone, temafloxacin-HCl (I), were compared with those of difloxacin and ciprofloxacin. I was as active as ciprofloxacin and difloxacin against staphylococci and as active as ciprofloxacin and more active than difloxacin against streptococci. Against gram-neg. enteric bacteria and Pseudomonas aeruginosa, I was more active than difloxacin but less active than ciprofloxacin. The min. inhibitory concentrations of I and difloxacin were higher in urine at pH 6.5 than in broth, and those of all 3 compounds were higher in serum than in broth. When administered orally in mouse protection tests, I was as active as difloxacin and ciprofloxacin against infections with Staphylococcus aureus and streptococci. Against infections with gram-neg. enteric bacteria and P. aeruginosa, I was as active as difloxacin and ciprofloxacin. I was 3 times less active than difloxacin but was 5 times more active than ciprofloxacin against infections with Salmonella typhimurium. 2 Was as active as difloxacin and ciprofloxacin against P. aeruginosa and Proteus mirabilis pyelonephritis in mice. The peak serum concentration and serum half-life of I in mice were approx. 50% and 16%, resp., those of difloxacin after oral administration. The peak serum concentration of I in mice after oral administration was 6 times higher than that of ciprofloxacin, and the serum half-life was equal to that of ciprofloxacin.
Antimicrobial Agents and Chemotherapy published new progress about temafloxacin antibacterial. 105784-61-0 belongs to class piperazines, name is Temafloxacin hydrochloride, and the molecular formula is C21H19ClF3N3O3, Synthetic Route of 105784-61-0.
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics