Nakanishi, Noriyuki published the artcileIn vitro activity of temafloxacin hydrochloride (TA-167 or A-62254), a new fluorinated 4-quinolone, Related Products of piperazines, the main research area is temafloxacin antibacterial activity.
The in vitro antibacterial activity of temafloxacin HCl was evaluated against a wide variety of clin. isolates and compared with those of other fluoroquinolones. The potency (MIC90) of the compound against gram-pos. aerobic bacteria was higher or comparable to those of ciprofloxacin, ofloxacin, and norfloxacin. Against most gram-neg. enteric bacteria and Pseudomonas species, temafloxacin was less active than ciprofloxacin, but was generally as active as ofloxacin and norfloxacin, except against Proteus species and Morganella morganii. Against obligate anaerobes, it was more active than the reference quinolones. Temafloxacin was bactericidal for 1 strain each of Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. The compound inhibited E. coli DNA gyrase activity at a low concentration
Chemotherapy (Basel, Switzerland) published new progress about temafloxacin antibacterial activity. 105784-61-0 belongs to class piperazines, name is Temafloxacin hydrochloride, and the molecular formula is C21H19ClF3N3O3, Related Products of piperazines.
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics