Segawa, Jun published the artcileStudies on pyridonecarboxylic acids. IV. Synthesis and antibacterial activity evaluation of S-(-)- and R-(+)-6-fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acids, Product Details of C18H20FN3O3S, the main research area is thiazetoquinolinecarboxylic acid synthesis antibacterial activity.
Optically active isomers of 6-fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid (NM394) were prepared through optical resolution of a racemic intermediate by high-performance liquid chromatog. The absolute configuration at the C-1 position in the thiazetoquinolone ring of the (-)-isomer was confirmed by X-ray anal. of to be S. The in vitro antibacterial activity of the (-)-isomer was 2-8 times that of the (+)-isomer.
Chemical & Pharmaceutical Bulletin published new progress about Crystal structure. 113028-17-4 belongs to class piperazines, name is Ethyl 6-fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate, and the molecular formula is C18H20FN3O3S, Product Details of C18H20FN3O3S.
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics