Wang, Guangjun published the artcileAn efficient synthesis of ABT-263, a novel inhibitor of antiapoptotic Bcl-2 proteins, Synthetic Route of 187669-28-9, the main research area is ABT263 Bcl2 protein inhibitor preparation.
ABT-263, a newly developed Bcl-2 inhibitor, was efficiently synthesized. The key intermediates 4-(4-{[2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-enyl]methyl}piperazin-1-yl)benzoic acid and 4-fluoro-3-[(trifluoromethyl)sulfonyl]benzenesulfonamide were efficiently prepared by a 3-component Mannich reaction and by nucleophilic fluorination of 1-nitro-2-[(trifluoromethyl)sulfonyl]benzene as the key steps, resp. Our work may lay a foundation for a new process development of this promising anticancer drug candidate.
Synthesis published new progress about Bcl-2 proteins Role: NUU (Other Use, Unclassified), USES (Uses) (inhibitors of). 187669-28-9 belongs to class piperazines, name is tert-Butyl 4-(piperazin-1-yl)benzoate, and the molecular formula is C15H22N2O2, Synthetic Route of 187669-28-9.
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics