Bryan, Marian C. published the artcilePyridones as Highly Selective, Noncovalent Inhibitors of T790M Double Mutants of EGFR, Application of 6-(4-Methylpiperazin-1-yl)pyridin-3-amine, the publication is ACS Medicinal Chemistry Letters (2016), 7(1), 100-104, database is CAplus and MEDLINE.
The rapid advancement of a series of noncovalent inhibitors of T790M mutants of EGFR is discussed. The optimization of a nonselective high-throughput screening pyridone hit to potent mols. with high levels of selectivity over wtEGFR and the broader kinome is described herein.
ACS Medicinal Chemistry Letters published new progress about 55403-35-5. 55403-35-5 belongs to piperazines, auxiliary class Pyridine,Piperazine,Amine, name is 6-(4-Methylpiperazin-1-yl)pyridin-3-amine, and the molecular formula is C10H16N4, Application of 6-(4-Methylpiperazin-1-yl)pyridin-3-amine.
Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics