Ding, Huaiwei published the artcileSynthesis and cytotoxic activity of some novel N-pyridinyl-2-(6-phenylimidazo[2,1-b]thiazol-3-yl)acetamide derivatives, HPLC of Formula: 55403-35-5, the publication is Molecules (2012), 4703-4716, database is CAplus and MEDLINE.
Novel compounds bearing imidazo[2,1-b]thiazole scaffolds were designed and synthesized based on the optimization of the virtual screening hit compound N-(6-morpholinopyridin-3-yl)-2-(6-phenylimidazo[2,1-b]thiazol-3-yl)acetamide (I) and were tested for their cytotoxicity against human cancer cell lines, including HepG2 and MDA-MB-231. 2-{6-(4-Chlorophenyl)imidazo[2,1-b]thiazol-3-yl}-N-{6-[4-(4-methoxybenzyl)piperazin-1-yl]pyridin-3-yl}acetamide, with slightly higher inhibition on VEGFR2 than I (5.72 and 3.76% inhibitory rate at 20 μM, resp.), was a potential inhibitor against MDA-MB-231 (IC50 = 1.4 μM) compared with sorafenib (IC50 = 5.2 μM), and showed more selectivity against MDA-MB-231 than HepG2 cell line (IC50 = 22.6 μM).
Molecules published new progress about 55403-35-5. 55403-35-5 belongs to piperazines, auxiliary class Pyridine,Piperazine,Amine, name is 6-(4-Methylpiperazin-1-yl)pyridin-3-amine, and the molecular formula is C10H16N4, HPLC of Formula: 55403-35-5.
Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics