Harmon, Shawn D. published the artcileEffect of the Δ6-desaturase inhibitor SC-26196 on PUFA metabolism in human cells, Related Products of piperazines, the publication is Lipids (2003), 38(4), 469-476, database is CAplus and MEDLINE.
The objective of this study was to determine the effect of 2,2-diphenyl-5-(4-{[(1E)-pyridin-3-yl-methylidene]-amino}piperazin-1-yl)pentanenitrile (SC-26196), a Δ6-desaturase inhibitor, on PUFA metabolism in human cells. SC-26196 inhibited the desaturation of 2 μM [1-14C]18:2n-6 by 87-95% in cultured human skin fibroblasts, coronary artery smooth muscle cells, and astrocytes. By contrast, SC-26196 did not affect the conversion of [1-14C]20:3n-6 to 20:4 in the fibroblasts, demonstrating that it is selective for Δ6-desaturase. The IC50 values for inhibition of the desaturation of 2 μM [1-14C]18:3n-3 and [3-14C]24:5n-3 in the fibroblasts, 0.2-0.4 μM, were similar to those for the inhibition of [1-14C]18:2n-6 desaturation, and the rates of recovery of [1-14C]18:2n-6 and [3-14C]24:5n-3 desaturation after removal of SC-26196 from the culture medium also were similar. SC-26196 reduced the conversion of [3-14C]22:5n-3 and [3-14C]24:5n-3 to DHA by 75 and 84%, resp., but it had no effect on the retroconversion of [3-14C]24:6n-3 to DHA. These results demonstrate that SC-26196 effectively inhibits the desaturation of 18- and 24-carbon PUFA and, therefore, decreases the synthesis of arachidonic acid, EPA, and DHA in human cells. Furthermore, they provide addnl. evidence that the conversion of 22:5n-3 to DHA involves Δ6-desaturation
Lipids published new progress about 218136-59-5. 218136-59-5 belongs to piperazines, auxiliary class Metabolic Enzyme,D6D, name is 2,2-Diphenyl-5-(4-((pyridin-3-ylmethylene)amino)piperazin-1-yl)pentanenitrile, and the molecular formula is C27H29N5, Related Products of piperazines.
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https://en.wikipedia.org/wiki/Piperazine,
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