Heeres, J. published the artcileAntimycotic azoles. 7. Synthesis and antifungal properties of a series of novel triazol-3-ones, Category: piperazines, the publication is Journal of Medicinal Chemistry (1984), 27(7), 894-900, database is CAplus and MEDLINE.
The antifungal triazolone derivatives I [R = H, Me, Q (X = N, CH); R1 = H, alkyl; R2 = H, Me) were prepared by a multistep sequence from 1-(p-methoxyphenyl)piperazine or MeSO3Q via piperazines III (R3 = H, Bz) and cyclization of III [R3 = C(:NH)NH2] with R2C(:NH)NH2. In vitro and in vivo antifungal properties of I are reported. Compound I [R = Q (X = N), R1 = MeEtCH, R2 = H], which displays a pronounced oral activity against vaginal candidosis in rats and against microsporosis in guinea pigs, was selected for clin. evaluation.
Journal of Medicinal Chemistry published new progress about 67914-60-7. 67914-60-7 belongs to piperazines, auxiliary class Piperazine,Benzene,Phenol,Amide, name is 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, and the molecular formula is C12H16N2O2, Category: piperazines.
Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics