Kaoukabi, Asma published the artcileEfficient Synthesis of New 2H-Chromene Retinoid Hybrid Derivatives by Suzuki Cross-Coupling Reactions, Recommanded Product: 1-Methyl-4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)sulfonyl)piperazine, the publication is Journal of Heterocyclic Chemistry (2019), 56(4), 1260-1274, database is CAplus.
In an attempt to improve anticancer activity, a series of retinoid-chromene hybrids were prepared The novel heterocyclic chromene-retinoid hybrids that include oxygen as a heteroatom in a six-membered cyclic ring (2H-chromene or 2H-1-benzopyran) were designed and synthesized by introducing different groups such as an aromatic or styrylphenyl group in the 6-position of 2H-chromene. These novel compounds were synthesized by using the efficient cascade one-pot process involving Wittig-Horner-Emmons reaction and Suzuki-Miyaura cross-coupling palladium-catalyzed reactions with 60% to 90% overall yields. These new compounds were tested against glioblastoma multiforme brain cancer, medulloblastoma, neuroblastoma cell lines and breast cancer MCF-7 cell lines. Two of them exhibited an appreciable antitumor activity in the low micromolar range, which opens new perspectives for therapeutic application on humans.
Journal of Heterocyclic Chemistry published new progress about 914610-39-2. 914610-39-2 belongs to piperazines, auxiliary class Piperazine,Boronic acid and ester,Sulfamide,Benzene,Piperazine,Boronate Esters,Boronic acid and ester,, name is 1-Methyl-4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)sulfonyl)piperazine, and the molecular formula is C17H27BN2O4S, Recommanded Product: 1-Methyl-4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)sulfonyl)piperazine.
Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics