Kim, Seong Heon published the artcileIII. Identification of novel CXCR3 chemokine receptor antagonists with a pyrazinyl-piperazinyl-piperidine scaffold, Quality Control of 207284-20-6, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(23), 6982-6986, database is CAplus and MEDLINE.
The SAR of a novel pyrazinyl-piperazinyl-piperidine scaffold with CXCR3 receptor antagonist activity was explored. Optimization of the DMPK profile and reduction of hERG inhibition is described. One compound with single-digit CXCR3 affinity and good rat PK and hERG profiles has been identified as a lead for further study.
Bioorganic & Medicinal Chemistry Letters published new progress about 207284-20-6. 207284-20-6 belongs to piperazines, auxiliary class Piperazine,Chiral, name is (S)-2-Ethylpiperazine, and the molecular formula is C6H14N2, Quality Control of 207284-20-6.
Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics